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L asparagine. The exact same reaction is achievable through two added reactions utilising an asparaginase/gluta minase and an L asparaginase which are also existing in S. Mbandaka. Galactose rate of metabolism map 00052 made 31/5/12 The 3 genes encoding merchandise required to feed D galactonate into glycolysis by conversion to D glyceraldehyde 3P are current on the chromosome of S. Mbandaka and absent from that of S. Derby. There are no substitute routes from D galactonate to glycolysis. full report Nitrogen rate of metabolism map 00910 created 21/eight/12 A gene coding for the enzyme L glutamine amido ligase that converts L glutamine to L glutamate employing a single molecule of H2O in the process is lacking from the chromosome of S. Derby D1. All strains con tain a gene that catalyses the similar reaction but with the need of a molecule of NADP as opposed to just one of H2O. Starch and sucrose metabolism mapDoxorubicin structure 00500 designed 9/seven/twelve A single reaction is missing from S. Mbandaka in this map for the conversion of alpha D Glucose one P to CDP glucose, there is no route to this com pound other than this on the map. The CDP glucose then prospects into amino sugar and nucleotide sugar meta bolism map 00520 made 19/1/ten. In this map there is an extra response from CDP glucose leading to CDP four keto 6 deoxy D Glucose lacking in S. Mbandaka. This reaction is catalysed by the enzyme RfbG, a CDP glucose 4,6 dehydratase which is discovered in Salmon ella enterica groups A, B, C2, C3, D1 and D2 and re quired for binding of the O antigen to the main oligosaccharide. S. Mbandaka is a member of S. enterica team C1. Streptomycin biosynthesis pathway map 00521 created 27/12/10 Two measures from D glucose one P are existing in each serovars, adhering to on from the terminal product of this reaction, two incorporate itional methods that direct to dTDP L rhamnose are missing in S. Mbandaka. dDTP L Rhamnose feeds directly into novobiocin biosynthesis, diverted out of the streptomycin biosynthesis pathway. S. Mbandaka is remaining with a product which feeds into polyketide sugar device biosynthesis. Salmonella pathogenicity islands The chromosome of Salmonella enterica contains largely of a core sequence punctuated with horizontally obtained sequences. The enhance of genomic islands inside the chromosome of Salmonella enterica can vary amongst isolates of the similar serovar. It has been postulated that the acquisition of horizon tally acquired genes into a Salmonella pathogenicity island led to the divergence of Salmonella from Escherichia coli. Salmonella pathogenicity island one is identified in all serovars of S. enterica and is very conserved. There are currently 22 posted Salmonella pathogenicity islands recognized from the ge nomes of Salmonella enterica and Salmonella bongori. The gene content of some of these islands is remarkably plastic


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